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If you take a dose of levodopa that equals less than 1500mg in a day, then you may be started on one tablet of sinemet 25 100mg three or four times a day.

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Although metoclopramide may increase the bioavailability of levodopa by increasing gastric emptyingmetoclopramide may also adversely affect disease control by its dopamine receptor antagonistic properties.

Gastrointestinal paindysphagiasialorrheaflatulencebruxismburning sensation of the tongueheartburnhiccups.

Carbidopa allows patients treated for Parkinson’s disease to use much lower doses of levodopaSome patients who responded poorly to levodopa have improved on SINEMETThis is most likely due to decreased peripheral decarboxylation of levodopa caused by administration of carbidopa rather than by a primary effect of carbidopa on the nervous systemCarbidopa has not been shown to enhance the intrinsic efficacy of levodopa.

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